He left her for dead in their home, but Martin managed to crawl out to the street and get to a hospital. She healed and spoke of her desire to make a boxing comeback in a moving interview on ESPN, but her dream never came true after she lost subsequent fights, including one in which she broke her hand in nine places. Stein was fascinated by this story of a celebrated fighter who had used her fists to make a living but who nevertheless became the victim of brutal violence. She was captivated, as well, by the saga of a survivor that did not end with the kind of victory widely proffered in popular culture. Martins experience hardly fits the mold of the expected Hollywood redemption saga, Stein, 39, said during a recent telephone interview. Those tend to be false narratives. Something horrible happens to a character, and then something strong inside them allows them to triumph somehow. foot surgery knee walkerBut thats not actually how traumatic experiences work. If you experience trauma in some form, that trauma will be with you for the rest of your life. Its like a scar. So Suli and I wanted to move away from the story of a survivor to a story of survival what really [can] happen to you when you have the rest of your life to live every day with that experience. The result is their play The Wholehearted, written and co-directed by Stein and co-directed and performed by Holum.
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With a better understanding of how this process is regulated, new targets for cancer treatments could be identified. Mitochondria, the organelles inside each cell that generate energy, play a crucial role in a tumor’s ability to generate the energy needed to invade healthy tissue. Mitochondria exhibit a remarkable ability to change theirshape and spatial distribution within a cell, said Raquel Sitcheran, PhD, assistant professor at the Texas College of Medicine and corresponding author of the study. We uncovered a surprising new regulator of mitochondrial dynamics that is important for promoting cancer cell invasion. This regulator, which is called NIK, is a protein that regulates immune cell function and inflammation. Their new finding is that NIK is also present on mitochondria in brain, pancreatic and breast cancer cells. When the research team removed all NIK expression using CRISPR -Cas9 genome editing, the cancer cells were no longer able to invade. On the other hand, NIK is upregulated when a cell becomes cancerous, and the more invasive tumors had higher activation of the NIK pathway. In cancer cells, mitochondria typically undergo fission and are small in size, allowing them to move rapidly to areas of the cell with high energy demandsusually the branches of a cell that are invading surrounding tissue. Without NIK, the mitochondria become fused and are impaired in their ability to move efficiently to areas of the cell that initiate and drive the process of invasion. Theres a link between NIK, mitochondrial function and cancer cell invasion, Sitcheran said. It gives us a new angle in thinking about the role of mitochondria in cancer progression. -more- Page 2 TEXAS A&M RESEARCHERS DISCOVER A NEW REGULATOR OF MITOCHONDRIA IN INVASIVE CANCER GROWTH To understand how this works, think of the mitochondriaunder normal circumstances, when they have plenty of NIKas being able to morph into different shapes, from a slow, hulking bus to a nimble race car.
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